Metabolite Identification

Physiologically based biokinetic (PBBK) model for safrole bioactivation and detoxification in rats

Type of publication: 
Matching Publication
Authors: 
E. Martati, M.G. Boersma, A. Spenkelink, D.B. Khadka, P.J. van Bladeren, I.M. Rietjens, A. Punt
Authors from the NMC: 
Published in: 
Chemical Research in Toxicology
Date of publication: 
2012/08
Status of the publication: 
Published/accepted
Pages: 
2011; 24 (6): 818-834
DOI: 
10.1021/tx200032m

Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein.

Type of publication: 
Matching Publication
Authors: 
A.M. Sotoca, M.D. Gelpke, S. Boeren, A. Ström, J.Å. Gustafsson, A.J. Murk, I.M.C.M. Rietjens, J.J.M. Vervoort
Authors from the NMC: 
Published in: 
Molecular & Cellular Proteomics
Date of publication: 
2011/01
Status of the publication: 
Published/accepted
Pages: 
2011; 10 (1): M110.002170
DOI: 
10.1074/mcp.M110.002170

Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria

Type of publication: 
Matching Publication
Authors: 
Y.C. Fiamegos, P.L. Kastritis, V. Exarchou, H. Han, A.M. Bonvin, J.J.M. Vervoort, K. Lewis, M.R. Hamblin, G.P. Tegos
Authors from the NMC: 
Published in: 
PLoS ONE
Date of publication: 
2011/04
Status of the publication: 
Published/accepted

BACKGROUND:

Pages: 
2011; 6 (4): e18127
DOI: 
10.1371/journal.pone.0018127

Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat

Type of publication: 
Matching Publication
Authors: 
A.A. Al-Subeihi, B. Spenkelink, N. Rachmawati, M.G. Boersma, A. Punt, J.J.M. Vervoort, P.J. van Bladeren, I.M.C.M. Rietjens
Authors from the NMC: 
Published in: 
Toxicology in Vitro
Date of publication: 
2011/02
Status of the publication: 
Published/accepted

The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene methyleugenol in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and physiological parameters derived from the literature.

Pages: 
2011; 25 (1): 267-285
DOI: 
10.1016/j.tiv.2010.08.019

Metabolic engineering of geranic acid in maize to achieve fungal resistance is compromised by novel glycosylation patterns

Type of publication: 
Matching Publication
Authors: 
T. Yang, G. Stoopen, N. Yalpani, J.J.M. Vervoort, R.C.H. de Vos, A. Voster, F.W. Verstappen, H.J. Bouwmeester, M.A. Jongsma
Authors from the NMC: 
Published in: 
Metabolic Engineering
Date of publication: 
2011/07
Status of the publication: 
Published/accepted

Many terpenoids are known to have antifungal properties and overexpression of these compounds in crops is a potential tool in disease control. In this study, 15 different mono- and sesquiterpenoids were tested in vitro against two major pathogenic fungi of maize (Zea mays), Colletotrichum graminicola and Fusarium graminearum. Among all tested terpenoids, geranic acid showed very strong inhibitory activity against both fungi (MIC<46 μM).

Pages: 
2011; 13 (4): 414-425
DOI: 
10.1016/j.ymben.2011.01.011

Changes in milk proteome and metabolome associated with dry period length, energy balance and lactation stage in post parturient dairy cows

Type of publication: 
Matching Publication
Authors: 
J. Lu, E. Antunes Fernandes, A.E. Páez Cano, J. Vinitwatanakhun, J.A. Boeren, T. van Hooijdonk, A. van Knegsel, J.J.M. Vervoort, K.A. Hettinga
Authors from the NMC: 
Published in: 
Journal of Proteome Research
Date of publication: 
2013/07
Status of the publication: 
Published/accepted
Pages: 
2013; 12 (7), 3288–3296
DOI: 
10.1021/pr4001306

Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling

Type of publication: 
Matching Publication
Authors: 
A.A. Al-Subeihi, W. Alhusainy, A. Paini, A. Punt, J.J.M. Vervoort, P.J. van Bladeren, I.M.C.M. Rietjens
Authors from the NMC: 
Published in: 
Food & Chemical Toxicology
Date of publication: 
2013/09
Status of the publication: 
Published/accepted

Methyleugenol (ME) occurs naturally in a variety of spices, herbs, including basil, and their essential oils. ME induces hepatomas in rodent bioassays following its conversion to a DNA reactive metabolite. In the present study, the basil constituent nevadensin was shown to be able to inhibit SULT-mediated DNA adduct formation in HepG2 cells exposed to the proximate carcinogen 1'-hydroxymethyleugenol in the presence of nevadensin.

Pages: 
2013; 59: 564-571
DOI: 
10.1016/j.fct.2013.06.043

Correlation between activation of PPARγ and resistin downregulation in a mouse adipocyte cell line by a series of thiazolidinediones

Type of publication: 
Matching Publication
Authors: 
A. Sotiriou, R.H. Blaauw, C. Meijer, L.H. Gijsbers, B. van der Burg, J.J.M. Vervoort, I.M. Rietjens
Authors from the NMC: 
Published in: 
Toxicology in Vitro
Date of publication: 
2013/04
Status of the publication: 
Published/accepted

The present study shows significant correlations between the EC50 for PPARγ activation in a reporter gene cell line and resistin downregulation in mouse adipocytes, and between the IC50 for resistin downregulation and the already published minimum effective dose for antihyperglycemic activity in a mouse model.

Pages: 
2013; 27 (5): 1425-1432
DOI: 
10.1016/j.tiv.2013.03.011

Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks

Type of publication: 
Matching Publication
Authors: 
I.M.C.M. Rietjens, A.M. Sotoca, J.J.M. Vervoort, J. Louisse
Authors from the NMC: 
Published in: 
Molecular Nutrition & Food Research
Date of publication: 
2013/01
Status of the publication: 
Published/accepted

Isoflavones are phytoestrogens that have been linked to both beneficial as well as adverse effects in relation to cell proliferation and cancer risks.

Pages: 
2013; 57 (1): 100-113
DOI: 
10.1002/mnfr.201200439

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

Type of publication: 
Matching Publication
Authors: 
E.F. Hoek-van den Hil, J. Keijer, A. Bunschoten, J.J.M. Vervoort, B. Stankova, M. Bekkenkamp, L. Herreman, D. Venema, P.C. Hollman, E. Tvrzicka, I.M. Rietjens, E.M. van Schothorst
Authors from the NMC: 
Published in: 
PLoS ONE
Date of publication: 
2013/01
Status of the publication: 
Published/accepted
Pages: 
2013; 8 (1): e51588
DOI: 
10.1371/journal.pone.0051588