Demonstration & Competence Lab (DCL)
The Demonstration and Competence Lab (DCL) offers a highly structured environment for advanced metabolomics studies. DCL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome. DCL is particularly geared towards biomarker discovery of human disease and health.
DCL works according to ISO17025 guidelines and employs rigorous quality standards, which ensures robust data that enable truly comparative studies.
DCL is the core facility of the Netherlands Metabolomics Centre (NMC) and its primary customers stem from the NMC consortium, but the facilities and expertise are available to external academic and industrial partners as well. DCL does not perform routine measurements, but operates at the frontier of metabolomics developments and opportunities. The DCL team covers the complete track from involvement in experimental design, study set-up and sample collection to the actual measurements, data analysis and comprehensive feedback on the results. In close collaboration with customers, DCL defines a tailor-made approach that offers the best fit between your biological question and optimal use of the potential of our highly advanced facilities.
Currently available DCL platforms:
| Platform | Number of metabolites in plasma |
| Lipid Profiling (LC-MS) | 300 |
| Bile acids (LC-MS) | 15 |
| Global Profiling (RP-UPLC-MS) | 250 |
| Global Profiling (GC-MS) | 120 |
| Oxylipins (LC-MS/MS) | 105 |
| Biogenic amines (Accq-tag\deriv. LC-MS/MS) | 85 |
Being embedded in the Netherlands Metabolomics Centre ensures that new technological opportunities are quickly recognized and further developed into new platforms. The DCL portfolio is therefore continuously improved and expanded.
More information & contact
For more information on technical details, access to DCL facilities and opportunities for collaboration, please contact Amy Harms, Senior Scientist at DCL, at: a.c.harms@lacdr.leidenuniv.nl