Sino-Dutch Centre for Preventive and Personalized Medicine (SDPPM)

Sino-Dutch Centre for Preventive and Personalized Medicine (SDPPM)

The SDPPM is a joint initiative of NGI/NMC and the Chinese Academy of Sciences/Dalian Institute of Chemical Physics, and has started in 2009 (www.sinodutchcentre.nl). In a joint research program, funded with an additional grant of € 1 million by the Netherlands Genomics Initiative, seven PhDs/postdocs in China and five PhDs/postdocs in the Netherlands aim to improve current diagnostics and to enable prevention-based approaches and to segregate patient populations (sub-typing) addressing the current responder/non-responder issues in Western medicine.

For the first time subtyping diabetes type 2 in an early phase has been established by integrating western and Chinese diagnosis in subtyping, allowing new personalized therapies to be fine-tuned. Rheumatoid arthritis subtyping was realized based on Chinese subtyping of rheumatoid arthritis patients and the underlying differential biochemical mechanism was revealed.  At its official opening on May 27th 2010 Minister of Economic Affairs Maria van der Hoeven was present and professor Chen Zhu, Minister of Health of the People’s Republic of China, gave a video message.  The first scientific SDPPM meeting with all researchers was held in Dalian, October 2010. To gain insights into the bottlenecks of the current healthcare system and to start to design the healthcare system of the future, the Health Innovation Lab initiative was started with 30 stakeholders and Otto Scharmer (MIT, US).

The objective is to improve current diagnostics and to enable prevention-based approaches and to segregate patient populations (sub-typing) addressing the current responder/non-responder issues in Western medicine. The research concentrates on the discovery of novel biomarkers for two important chronic disease areas: type 2 diabetes and arthritis (osteoarthritis and rheumatoid arthritis). Diagnostic discovery strategies will be based on “Disease phenotyping using metabolomics-based Systems Biology” and “ultra-weak photon emission”.

Project overview

Effect of ginseng on diabetes 
Ms. Chunxiu Hu

Diagnosis of arthritis
Mr. Herman van Wietmarschen

Diagnosis and subtypes of Diabetes Type 2 
Ms. Heng Wei

Biophoton measurements, an electromagnetic model for living systems 
Dr. Eduard van Wijk

A comprehensive metabolomic study: plasma and urine metabolic profiling of rheumatoid arthritis
Mr. Weidong Dai

Human serum metabolomics analysis reflects metabolic differences of glucose intolerance statuses 
Ms. Yan Gu

GCxGC-TOFMS based metabolomics: biomarker discovery for diabetes 
Mr. Xiang Li

Metabolomic study of lifestyle intervention on pre-diabetic 
Ms. Xinjie Zhao

Metabolomic analysis of urine samples from type 2 diabetic rats treated with rhizoma coptidis using gas chromatography/time-of-flight mass spectrometry 
Mr. Jing Wang

A novel method for the QA/QC of Chinese Herbal Medicine 
Dr. Hongwei Kong

Metabolic profiling to evaluate the preventive effects of different pharmacodynamic extracts from Denshen (Radix Salviae Miltiorrhiae) and Sanchi (Radix Notoginseng) against acute blood stasis rat model in Chinese medicine 
Mr. Zheming Wu