Authors:
D.J. Vis, J.A. Westerhuis, H.C.J. Hoefsloot, F. Roelfsema, M.M.W.B. Hendriks, A.K. Smilde
The regulatory mechanisms underlying pulsatile secretion are complex, especially as it is partly controlled by other hormones and the combined action of multiple agents. Regulatory relations between hormones are not directly observable but may be deduced from time series measurements of plasma hormone concentrations. Variation in plasma hormone levels are the resultant of secretion and clearance from the circulation. A strategy is proposed to extract inhibition, activation, thresholds and circadian synchronicity from concentration data, using particular association methods.
DOI:
10.1371/journal.pone.0032985