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Quantitative Profiling

Improving the analysis of designed studies by combining statistical modelling with study design information

Authors: 
U. Thissen, S.Wopereis, S.A.A. van den Berg, I.Bobeldijk, R. Kleemann, T. Kooistra, K.Willems van Dijk, B. van Ommen and A.K. Smilde

doi:10.1186/1471-2105-10-52

Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.

Authors: 
de Keizer PL, Packer LM, Szypowska AA, Riedl-Polderman PE, van den Broek NJ, de Bruin A, Dansen TB, Marais R, Brenkman AB*, Burgering BM

Comprehensive LC-MS(E) Lipidomic Analysis using a Shotgun Approach and Its Application to Biomarker Detection and Identification in Osteoarthritis Patients

Authors: 
Castro-Perez JM, Kamphorst J, Degroot J, Lafeber F, Goshawk J, Yu K, Shockcor JP, Vreeken RJ, Hankemeier T

Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low-abundant peptides in biofluids

Authors: 
Kamphorst JJ, Tjaden UR, van der Heijden R, DeGroot J, van der Greef J, Hankemeier T

DOI: 10.1002/elps.200800500

Equating or Correction for Between-Block Effects with Application to Body Fluid LC-MS and NMR Metabolomics Data Sets

Authors: 
H. Draisma, T. Reijmers, F. van der Kloet, I. Bobeldijk-Pastorova, E. Spies-Faber, J. Vogels, J. Meulman, D. Boomsma, J. van der Greef, T. Hankemeier
DOI: 10.1021/ac902346a

Quantitative profiling

Short description: 
The aim of Quantitative Profiling is to develop a generation of metabolomics platforms inspired by biology and driven by technological opportunities. Platforms for phosphopeptide, oxy-lipid and isoprostane analysis have been developed and validated and are being applied to urgent biological questions related to chronic inflammatory disorders, regulation of life span and oxidative stress.

The aim of the NMC Quantitative Profiling (QP) Theme is to develop a new generation of metabolomics platforms inspired by biology and driven by technological opportunities. Two groups of projects can be distinguished:

Theme leader

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