Biomedical

Increase in short‐chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

Biomedical

Authors:

M. Janssens, J. van Smeden, G.S. Gooris, W. Bras, G. Portale, P.J. Caspers, R.J. Vreeken, T. Hankemeier, S. Kezic, R. Wolterbeek, A.P. Lavrijsen, J.A. Bouwstra

A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central role in the pathogenesis of AE. Nevertheless, the precise causes of AE-associated barrier dysfunction are largely unknown.

DOI:

10.1194/jlr.P030338

Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes

Biomedical

Authors:

H. Wei, W. Pasman, C. Rubingh, S. Wopereis, M. Tienstra, J. Schroen, M. Wang, E. Verheij, J. van der Greef

The prevalence of type 2 diabetes continuously increases globally. A personalized strategy applied in the pre-diabetic stage is vital for diabetic prevention and management. The personalized diagnosis of Chinese Medicine (CM) may help to stratify the diabetics. Metabolomics is regarded as a potential platform to provide biomarkers for disease-subtypes. We designed an explorative study of 50 pre-diabetic males, combining GC-MS urine metabolomics with CM diagnosis in order to identify diagnostic biomarkers for pre-diabetic subtypes.

DOI:

10.1039/c2mb05445k

Ultra-weak photon emission from organisms

Biomedical

Authors:

E. van Wijk, Y. Yan

This talk, ultra-weak photon emission from living systems, covers three issues. The first issue deals with the detection of biological radiation. The development of photomultipliers and their general properties. The second issue deals with the developments in the evidence for photons originating from living systems from cells to human. The last issue deals with the non-linear relation between cell number and photon count (DL) and as illustration we use photon emission research in tumor biology.

Metabolite Space of Rheumatoid Arthritis

Biomedical

Authors:

H. van Wietmarschen, J. van der Greef

Metabolites play numerous roles in the healthy and diseased body, ranging from regulating physiological processes to providing building blocks for the body. Therefore, understanding the role of metabolites is important in elucidating the etiology and pathology of diseases and finding targets for new treatment options. Rheumatoid arthritis is a complex chronic disease for which new disease management strategies are needed.

Human Photon Dynamics Determined by Using Photon Count Statistics

Biomedical

Authors:

E.P.A. van Wijk, J. van der Greef, R. van Wijk

Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice

Biomedical

Authors:

C. Hu, H. Wei, A.M. van den Hoek, M. Wang, R. van der Heijden, G. Spijksma, T.H. Reijmers, J. Bouwman, S. Wopereis, L.M. Havekes, E. Verheij, T. Hankemeier, G.W. Xu, J. van der Greef

Abstract

Background
Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m² with associated risk factors such as type II diabetes and dyslipidaemia in the past.

Photon Counts Statistics in Leukocyte Cell

Biomedical

Authors:

E. van Wijk, J. van der Greef, R. van Wijk

In the present experiment ultra-weak photon emission/ chemiluminescence from isolated neutrophils was recorded. It is associated with the production of reactive oxygen species (ROS) in the “respiratory burst” process which can be activated by PMA (Phorbol 12-Myristate 13-Acetate). Commonly, the reaction is demonstrated utilizing the enhancer luminol. However, with the use of highly sensitive photomultiplier equipment it is also recorded without enhancer.

DOI:

doi:10.1088/1742-6596/329/1/012021

Characterization of Rheumatoid Arthritis Subtypes Using Symptom Profiles, Clinical Chemistry and Metabolomics Measurements

Biomedical

Authors:

H.A. van Wietmarschen, W. Dai, A.J. van der Kooij, T.H. Reijmers, Y. Schroën, M. Wang, Z. Xu, X. Wang, H. Kong, G. Xu, T. Hankemeier, J.J. Meulman, J. van der Greef

OBJECTIVE:

The aim is to characterize subgroups or phenotypes of rheumatoid arthritis (RA) patients using a systems biology approach. The discovery of subtypes of rheumatoid arthritis patients is an essential research area for the improvement of response to therapy and the development of personalized medicine strategies.