Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum)

This case-series describes fourteen horses suspected of equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) also known as atypical myopathy of which seven cases were confirmed biochemically with all horses having had access to leaves of the Maple tree (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum). Assessment of organic acids, glycine conjugates, and acylcarnitines in urine was regarded as gold standard in the biochemical diagnosis of equine acquired multiple acyl-CoA dehydrogenase deficiency.

Authors: 
J.H. van der Kolk, I.D. Wijnberg, C.M. Westermann, L. Dorland, M.G. de Sain-van der Velden, L.C. Kranenburg, M. Duran, J.A. Dijkstra, J.J. van der Lugt, R.J. Wanders, E. Gruys
Authors from the NMC: 
DOI: 
10.1016/j.ymgme.2010.06.019
Pages: 
2010; 101 (2-3): 289-291
Published in: 
Molecular Genetics & Metabolism
Date of publication: 
October, 2010
Status of the publication: 
Published/accepted